This article analyzes the possibilities of situated curatorial activism and its capacity to activate anti-colonial and descolonial processes for social justice within the museum institution; based on the case of Las Guerreras del centro, a community of female sex workers who work in the surroundings of the Museo de Antioquia (Medellín, Colombia, who participated in a purposeful and authorial way in five projects within the same, between 2016 and 2018.